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Mouse Anti-CPT1A Recombinant Antibody (CBFYC-2169) (V2LY-1206-LY998)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2169
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
Residues surrounding amino acid 501 of human CPT1A protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC3-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carnitine Palmitoyltransferase 1A
Entrez Gene ID
1374
UniProt ID
P50416
Function
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221).

Plays an important role in hepatic triglyceride metabolism (By similarity).
Biological Process
Carnitine metabolic process Source: UniProtKB
Carnitine shuttle Source: Reactome
Cellular response to fatty acid Source: Ensembl
Eating behavior Source: Ensembl
Epithelial cell differentiation Source: UniProtKB
Fatty acid beta-oxidation Source: ProtInc
Fatty acid metabolic process Source: GO_Central
Glucose metabolic process Source: Ensembl
Liver regeneration Source: Ensembl
Long-chain fatty acid metabolic process Source: UniProtKB
Positive regulation of fatty acid beta-oxidation Source: Ensembl
Regulation of insulin secretion Source: Ensembl
Regulation of lipid storage Source: Ensembl
Response to alkaloid Source: Ensembl
Response to antibiotic Source: Ensembl
Response to drug Source: Ensembl
Response to ethanol Source: Ensembl
Response to nutrient levels Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to tetrachloromethane Source: Ensembl
Triglyceride metabolic process Source: Ensembl
Cellular Location
Mitochondrion outer membrane
Involvement in disease
Carnitine palmitoyltransferase 1A deficiency (CPT1AD):
Rare autosomal recessive metabolic disorder of long-chain fatty acid oxidation characterized by severe episodes of hypoketotic hypoglycemia usually occurring after fasting or illness. Onset is in infancy or early childhood.
Topology
Cytoplasmic: 2-47
Helical: 48-73
Mitochondrial intermembrane: 74-102
Helical: 103-122
Cytoplasmic: 123-773
More Infomation

Fondevila, M. F., Fernandez, U., Heras, V., Parracho, T., Gonzalez-Rellan, M. J., Novoa, E., ... & Nogueiras, R. (2022). Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis. Journal of Hepatology.

Tan, Z., Zou, Y., Zhu, M., Luo, Z., Wu, T., Zheng, C., ... & Lu, Z. (2021). Carnitine palmitoyl transferase 1A is a novel diagnostic and predictive biomarker for breast cancer. BMC cancer, 21(1), 1-16.

Trabjerg, M. S., Andersen, D. C., Huntjens, P., Oklinski, K. E., Bolther, L., Hald, J. L., ... & Nieland, J. D. V. (2021). Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS. Communications Biology, 4(1), 1-23.

Wang, L., Li, C., Song, Y., & Yan, Z. (2020). Inhibition of carnitine palmitoyl transferase 1A-induced fatty acid oxidation suppresses cell progression in gastric cancer. Archives of Biochemistry and Biophysics, 696, 108664.

Trabjerg, M. S., Mørkholt, A. S., Lichota, J., Oklinski, M. K. E., Andersen, D. C., Jønsson, K., ... & Nieland, J. D. V. (2020). Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models. Scientific RepoRtS, 10(1), 1-19.

Mørkholt, A. S., Oklinski, M. K., Larsen, A., Bockermann, R., Issazadeh-Navikas, S., Nieland, J. G. K., ... & Nieland, J. D. V. (2020). Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents. Plos one, 15(6), e0234493.

Moody, L., Xu, G. B., Chen, H., & Pan, Y. X. (2019). Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862(2), 141-152.

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W. I., Lou, Z., ... & Hitosugi, T. (2018). Carnitine palmitoyltransferase 1A has a lysine succinyltransferase activity. Cell reports, 22(6), 1365-1373.

Warfel, J. D., Vandanmagsar, B., Dubuisson, O. S., Hodgeson, S. M., Elks, C. M., Ravussin, E., & Mynatt, R. L. (2017). Examination of carnitine palmitoyltransferase 1 abundance in white adipose tissue: implications in obesity research. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 312(5), R816-R820.

Mørkholt, A. S., Wiborg, O., Nieland, J. G., Nielsen, S., & Nieland, J. D. (2017). Blocking of carnitine palmitoyl transferase 1 potently reduces stress-induced depression in rat highlighting a pivotal role of lipid metabolism. Scientific reports, 7(1), 1-9.

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For research use only. Not intended for any clinical use.

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