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Mouse Anti-CPNE1 Recombinant Antibody (CBFYC-2162) (V2LY-1206-LY970)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2162
Antibody Isotype
IgG2a, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Recombinant human copine 1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Copine 1
Entrez Gene ID
8904
UniProt ID
Q99829
Function
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885).

Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885).

Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605).

Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385).

May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145).

May function in membrane trafficking (PubMed:9430674).

Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740).

Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
Biological Process
Cellular response to calcium ion Source: UniProtKB
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Neuron projection extension Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Vesicle-mediated transport Source: ProtInc
Cellular Location
Nucleus; Cell membrane; Cytoplasm. Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).
More Infomation

Wang, Y., Pan, S., He, X., Wang, Y., Huang, H., Chen, J., ... & Qin, X. (2021). CPNE1 enhances colorectal cancer cell growth, glycolysis, and drug resistance through regulating the AKT-GLUT1/HK2 Pathway. OncoTargets and therapy, 14, 699.

Du, W., Liu, T., Zhang, Y., Zeng, Y., Zhu, J., Tang, H., ... & Huang, J. A. (2020). MiR-195-5p is a potential factor responsible for CPNE1 differential expression between subtypes of non-small cell lung cancer. Journal of Cancer, 11(9), 2610.

Shao, Z., Ma, X., Zhang, Y., Sun, Y., Lv, W., He, K., ... & Gao, X. (2020). CPNE1 predicts poor prognosis and promotes tumorigenesis and radioresistance via the AKT singling pathway in triple‐negative breast cancer. Molecular carcinogenesis, 59(5), 533-544.

Choi, H. Y., Park, N., Lee, B., Choe, Y. I., Woo, D. K., Park, J. Y., & Yoo, J. C. (2020). CPNE1-mediated neuronal differentiation can be inhibited by HAX1 expression in HiB5 cells. Biochemical and biophysical research communications, 533(3), 319-324.

Kim, T. H., Sung, S. E., Yoo, J. C., Park, J. Y., Yi, G. S., Heo, J. Y., ... & Lee, D. Y. (2018). Copine1 regulates neural stem cell functions during brain development. Biochemical and biophysical research communications, 495(1), 168-173.

Liu, S., Tang, H., Zhu, J., Ding, H., Zeng, Y., Du, W., ... & Huang, J. A. (2018). High expression of Copine 1 promotes cell growth and metastasis in human lung adenocarcinoma. International journal of oncology, 53(6), 2369-2378.

Tang, H., Zhu, J., Du, W., Liu, S., Zeng, Y., Ding, Z., ... & Huang, J. (2018). CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer. Journal of Experimental & Clinical Cancer Research, 37(1), 1-15.

Jiang, Z., Jiang, J., Zhao, B., Yang, H., Wang, Y., Guo, S., ... & Wang, J. (2018). CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells. Oncology reports, 39(2), 643-650.

Yoo, J. C., Park, N., Lee, B., Nashed, A., Lee, Y. S., Kim, T. H., ... & Park, J. Y. (2017). 14-3-3γ regulates Copine1-mediated neuronal differentiation in HiB5 hippocampal progenitor cells. Experimental cell research, 356(1), 85-92.

Liang, J., Zhang, J., Ruan, J., Mi, Y., Hu, Q., Wang, Z., & Wei, B. (2017). CPNE1 is a useful prognostic marker and is associated with TNF receptor-associated factor 2 (TRAF2) expression in prostate cancer. Medical science monitor: international medical journal of experimental and clinical research, 23, 5504.

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For research use only. Not intended for any clinical use.

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