Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-COQ2 Recombinant Antibody (C4690) (V2LY-1206-LY787)


See all COQ2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
C4690
Antibody Isotype
IgG1, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Amino acids 84-132 representing partial length COQ2 of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
coenzyme Q2 homolog, prenyltransferase (yeast)
Entrez Gene ID
27235
UniProt ID
Q96H96
Function
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Biological Process
Glycerol metabolic process Source: UniProtKB
Isoprenoid biosynthetic process Source: UniProtKB-UniRule
Ubiquinone biosynthetic process Source: UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Coenzyme Q10 deficiency, primary, 1 (COQ10D1):
An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.
Multiple system atrophy 1 (MSA1):
A progressive neurodegenerative disorder clinically characterized by parkinsonism, cerebellar ataxia, and autonomic, urogenital, and pyramidal dysfunction in various combinations. Pathologically, it is characterized by degeneration of striatonigral and olivopontocerebellar structures, and glial cytoplasmic inclusions that consist of abnormally phosphorylated alpha-synuclein or tau.
Topology
Mitochondrial matrix: 35-83
Helical: 84-104
Mitochondrial intermembrane: 105-108
Helical: 109-129
Mitochondrial matrix: 130-148
Helical: 149-169
Mitochondrial intermembrane: 170-172
Helical: 173-193
Mitochondrial matrix: 194-203
Helical: 204-224
Mitochondrial intermembrane: 225-231
Helical: 232-252
Mitochondrial matrix: 253-277
Helical: 278-298
Mitochondrial intermembrane: 299-300
Helical: 301-321
Mitochondrial matrix: 322-332
Helical: 333-353
Mitochondrial intermembrane: 354-371
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-COQ2 Recombinant Antibody (C4690)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry