Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-COL3A1 Recombinant Antibody (CBYY-C3184) (CBMAB-C4627-YY)


See all COL3A1 antibodies
Online Inquiry
Published Data
CBMAB-C4627-YY-1
Rabbit Anti-COL3A1 Recombinant Antibody (CBYY-C3184) (CBMAB-C4627-YY) in WB
Expression of cardiac protein in the marginal zone of left ventricular infarction (Collagen-1 protein levels of heart: t (4) = 3.421, P< 0.05 by independent t-tests; MI+Dio = 3, MI+taCasp3 = 3. Collagen-3 protein levels of heart: t (4) = 7.021, P< 0.01 by independent t-tests; MI+Dio = 3, MI+taCasp3 = 3. TH protein levels of heart: t (4) = 3.403, P< 0.05 by independent t-tests; MI+Dio = 3, MI+taCasp3 = 3). ...View More
Bo, W., Cai, M., Ma, Y., Di, L., Geng, Y., Li, H., ... & Tian, Z. (2024). Manipulation of glutamatergic neuronal activity in the primary motor cortex regulates cardiac function in Normal and myocardial infarction mice. Advanced Science, 11(20), 2305581.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYY-C3184
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Immunogen
Recombinant fragment of human Collagen III.
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Collagen Type III Alpha 1 Chain
Entrez Gene ID
UniProt ID
Human1281
Mouse12825
Alternative Names
Collagen Type III Alpha 1 Chain; Ehlers-Danlos Syndrome Type IV, Autosomal Dominant; Collagen, Type III, Alpha 1; Collagen Alpha-1(III) Chain; Alpha-1 Type III Collagen; Alpha1 (III) Collagen; Collagen, Fetal; EDSVASC; EDS4A;
Function
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Biological Process
Cell-matrix adhesion Source: UniProtKB
Cerebral cortex development Source: UniProtKB
Collagen fibril organization Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Heart development Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Negative regulation of immune response Source: UniProtKB
Negative regulation of neuron migration Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Platelet activation Source: UniProtKB
Positive regulation of Rho protein signal transduction Source: UniProtKB
Regulation of immune response Source: Reactome
Response to cytokine Source: UniProtKB
Response to mechanical stimulus Source: Ensembl
Response to radiation Source: UniProtKB
Skeletal system development Source: Ensembl
Skin development Source: UniProtKB
Supramolecular fiber organization Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Wound healing Source: UniProtKB
Cellular Location
Extracellular matrix
Involvement in disease
Ehlers-Danlos syndrome, vascular type (EDSVASC):
A severe form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSVASC is an autosomal dominant disease characterized by joint and dermal manifestations as in other forms of the syndrome, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome (PMGEDSV):
An autosomal recessive disorder with a highly variable phenotype and onset in early childhood. Disease features include cobblestone-like malformation of the cortex, polymicrogyria, intellectual and motor developmental delay, small joint hypermobility, vascular fragility, aneurysms, thin translucent skin and easy bruising, congenital heart defects, and foot deformities. Early death due to vascular dissection may occur.
PTM
Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
More Infomation

Niu, K., Chen, X., & Lu, Y. (2021). COL3A1 rs1800255 polymorphism is associated with pelvic organ prolapse susceptibility in Caucasian individuals: Evidence from a meta-analysis. PloS one, 16(4), e0250943.

Mamoor, S. (2021). Differential expression of collagen type III alpha 1 chain in human epithelial ovarian cancer.

Huang, R., Li, Z., Zhu, X., Yan, P., Song, D., Yin, H., ... & Huang, Z. (2020). Collagen Type III Alpha 1 chain regulated by GATA‐Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. Journal of cellular and molecular medicine, 24(18), 10803-10815.

Shi, Y., Zheng, C., Jin, Y., Bao, B., Wang, D., Hou, K., ... & Teng, Y. (2020). Reduced expression of METTL3 promotes metastasis of triple-negative breast cancer by m6A methylation-mediated COL3A1 up-regulation. Frontiers in oncology, 1126.

Teixeira, F. H., Fernandes, C. E., do Souto, R. P., & de Oliveira, E. (2020). Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse. International urogynecology journal, 31(1), 73-78.

Kuivaniemi, H., & Tromp, G. (2019). Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene, 707, 151-171.

Ballengee, C. R., Stidham, R. W., Liu, C., Kim, M. O., Prince, J., Mondal, K., ... & Kugathasan, S. (2019). Association between plasma level of collagen type III alpha 1 chain and development of strictures in pediatric patients with Crohn’s disease. Clinical Gastroenterology and Hepatology, 17(9), 1799-1806.

Engqvist, H., Parris, T. Z., Kovács, A., Nemes, S., Werner Rönnerman, E., De Lara, S., ... & Helou, K. (2019). Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas. BMC cancer, 19(1), 1-12.

D'hondt, S., Guillemyn, B., Syx, D., Symoens, S., De Rycke, R., Vanhoutte, L., ... & Malfait, F. (2018). Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model. Matrix Biology, 70, 72-83.

Shi, J., Ma, X., Gao, Y., Fan, D., Zhu, C., Mi, Y., & Xue, W. (2017). Hydroxylation of human type III collagen alpha chain by recombinant coexpression with a viral prolyl 4-hydroxylase in Escherichia coli. The Protein Journal, 36(4), 322-331.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-COL3A1 Recombinant Antibody (CBYY-C3184)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry
HumanP02461
MouseP08121