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Rabbit Anti-CNR1 (phospho S316) Recombinant Antibody (BA0195) (CBMAB-0245CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0195
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Immunogen
Human Cannabinoid Receptor I aa 300-400 (phospho S316)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
Entrez Gene ID
1268
UniProt ID
P21554
Alternative Names
Cannabinoid Receptor 1 (Brain); CANN6; CB-R; CNR; CB1; Central Cannabinoid Receptor; CB1K5; CB1A; CB1R
More Infomation

Beins, E. C., Beiert, T., Jenniches, I., Hansen, J. N., Leidmaa, E., Schrickel, J. W., & Zimmer, A. (2021). Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress. Translational psychiatry, 11(1), 1-15.

Szejko, N., Fichna, J. P., Safranow, K., Dziuba, T., Żekanowski, C., & Janik, P. (2020). Association of a variant of CNR1 gene encoding cannabinoid receptor 1 with gilles de la Tourette syndrome. Frontiers in genetics, 11, 125.

Peiró, A. M., García-Gutiérrez, M. S., Planelles, B., Femenía, T., Mingote, C., Jiménez-Treviño, L., ... & Manzanares, J. (2020). Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder. Anxiety, Stress, & Coping, 33(3), 256-265.

Tao, R., Li, C., Jaffe, A. E., Shin, J. H., Deep-Soboslay, A., Yamin, R. E., ... & Kleinman, J. E. (2020). Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia. Translational psychiatry, 10(1), 1-13.

Li, M., Qian, X., Zhu, M., Li, A., Fang, M., Zhu, Y., & Zhang, J. (2018). miR‑1273g‑3p promotes proliferation, migration and invasion of LoVo cells via cannabinoid receptor 1 through activation of ERBB4/PIK3R3/mTOR/S6K2 signaling pathway. Molecular Medicine Reports, 17(3), 4619-4626.

Hou, Q., Huang, Y., Zhang, C., Zhu, S., Li, P., Chen, X., ... & Liu, F. (2018). MicroRNA-200a targets cannabinoid receptor 1 and serotonin transporter to increase visceral hyperalgesia in diarrhea-predominant irritable bowel syndrome rats. Journal of neurogastroenterology and motility, 24(4), 656.

Yao, Y., Xu, Y., Zhao, J., Ma, Y., Su, K., Yuan, W., ... & Li, M. D. (2018). Detection of significant association between variants in cannabinoid receptor 1 Gene (CNR1) and personality in African–American population. Frontiers in genetics, 9, 199.

Sidibeh, C. O., Pereira, M. J., Lau Börjesson, J., Kamble, P. G., Skrtic, S., Katsogiannos, P., ... & Eriksson, J. W. (2017). Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. Endocrine, 55(3), 839-852.

Ketcherside, A., Noble, L. J., McIntyre, C. K., & Filbey, F. M. (2017). Cannabinoid receptor 1 gene by cannabis use interaction on CB1 receptor density. Cannabis and cannabinoid research, 2(1), 202-209.

Rowley, S., Sun, X., Lima, I. V., Tavenier, A., de Oliveira, A. C. P., Dey, S. K., & Danzer, S. C. (2017). Cannabinoid receptor 1/2 double‐knockout mice develop epilepsy. Epilepsia, 58(12), e162-e166.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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