Mouse Anti-CNIH3 Recombinant Antibody (1E10) (CBMAB-C3904-LY)

Name: Mouse Anti-CNIH3 Recombinant Antibody (1E10)
SKU: CBMAB-C3904-LY
Rating: 5 (1 reviews)

See all CNIH3 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1E10

Antibody Isotype

IgG2b, κ

Application

ELISA

Basic Information

Immunogen

Full length recombinant CNIH3.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

cornichon family AMPA receptor auxiliary protein 3

Introduction

CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include Schizophrenia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH2.

Entrez Gene ID

149111

UniProt ID

Q8TBE1

Alternative Names

Cornichon Family AMPA Receptor Auxiliary Protein 3; CNIH-3; Cornichon Homolog 3 (Drosophila); Protein Cornichon Homolog 3; Cornichon Homolog 3;

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Biological Process

COPII vesicle coating Source: Reactome
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Regulation of AMPA receptor activity Source: UniProtKB
Regulation of membrane potential Source: Ensembl
Synaptic transmission, glutamatergic Source: Ensembl

Cellular Location

Postsynaptic cell membrane. Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).

Topology

Cytoplasmic: 1-10
Helical: 11-31
Lumenal: 32-72
Helical: 73-93
Cytoplasmic: 94-138
Helical: 139-159
Lumenal: 160

More Infomation

References

Ramos-Vicente, D., & Bayés, À. (2020). AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins. Open biology, 10(10), 200234.

von Engelhardt, J. (2019). AMPA receptor auxiliary proteins of the CKAMP family. International journal of molecular sciences, 20(6), 1460.

Jacobi, E., & von Engelhardt, J. (2018). AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization. Molecular and Cellular Neuroscience, 91, 67-75.

Brown, P. M., McGuire, H., & Bowie, D. (2018). Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation. Journal of General Physiology, 150(1), 67-82.

Hawken, N. M., Zaika, E. I., & Nakagawa, T. (2017). Engineering defined membrane‐embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin. The Journal of Physiology, 595(20), 6517-6539.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-CNIH3 Recombinant Antibody (1E10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: