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Mouse Anti-CLCF1 Recombinant Antibody (CBWJN-0663) (CBMAB-N0683-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0663
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Human recombinant CLC.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cardiotrophin Like Cytokine Factor 1
Introduction
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Entrez Gene ID
23529
UniProt ID
Q9UBD9
Alternative Names
Cardiotrophin Like Cytokine Factor 1; Novel Neurotrophin-1; CRLF1 Associated Cytokine-Like Factor 1; B-Cell-Stimulating Factor 3; BSF-3; NNT-1; BSF3; NNT1; CLC;
Function
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Biological Process
B cell differentiation Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: Reactome
Negative regulation of neuron apoptotic process Source: BHF-UCL
Positive regulation of astrocyte differentiation Source: BHF-UCL
Positive regulation of B cell proliferation Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of immunoglobulin production Source: BHF-UCL
Positive regulation of isotype switching to IgE isotypes Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Crisponi/Cold-induced sweating syndrome 2 (CISS2):
An autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
More Infomation

Yokota, S., Matsumae, G., Shimizu, T., Hasegawa, T., Ebata, T., Takahashi, D., ... & Iwasaki, N. (2021). Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway. Bone, 153, 116140.

Lei, M. M. L., & Lee, T. K. W. (2021). Cancer‐Associated Fibroblasts: Orchestrating the Crosstalk Between Liver Cancer Cells and Neutrophils Through the Cardiotrophin‐Like Cytokine Factor 1–Mediated Chemokine (C‐X‐C motif) Ligand 6/TGF‐β Axis. Hepatology, 73(5), 1631-1633.

Chen, X., Li, J., Ye, Y., Huang, J., Xie, L., Chen, J., ... & Ge, J. (2021). Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women. BMC musculoskeletal disorders, 22(1), 1-9.

Laplante, V., Nadeau, U., Rousseau, M., Lesage, S., Gauchat, J. F., & Pasquin, S. (2021). Detection of Cardiotrophin-like Cytokine Factor 1 (CLCF1) by flow cytometry.

Pasquin, S., Tormo, A., Moreau, J., Laplante, V., Sharma, M., Gauchat, J. F., & Rafei, M. (2019). Cardiotrophin-like cytokine factor 1 exhibits a myeloid-biased hematopoietic-stimulating function. Frontiers in immunology, 10, 2133.

Nahlé, S., Pasquin, S., Laplante, V., Rousseau, F., Sharma, M., & Gauchat, J. F. (2019). Cardiotrophin-like cytokine (CLCF1) modulates mesenchymal stem cell osteoblastic differentiation. Journal of Biological Chemistry, 294(32), 11952-11959.

Pasquin, S., Chehboun, S., Dejda, A., Meliani, Y., Savin, V., Warner, G. J., ... & Gauchat, J. F. (2018). Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity. Scientific reports, 8(1), 1-14.

Ge, J. R., Xie, L. H., Chen, J., Li, S. Q., Xu, H. J., Lai, Y. L., ... & Ni, C. B. (2018). Liuwei Dihuang Pill treats postmenopausal osteoporosis with Shen (Kidney) yin deficiency via Janus kinase/signal transducer and activator of transcription signal pathway by up-regulating cardiotrophin-like cytokine factor 1 expression. Chinese journal of integrative medicine, 24(6), 415-422.

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For research use only. Not intended for any clinical use.

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