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Mouse Anti-CLCA2 Recombinant Antibody (CBFYC-1898) (CBMAB-C1963-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBFYC-1898
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 601-660 mapping within an internal region of Clca2 of mouse.
Host Species
Mouse
Specificity
Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 300-400

Target

Full Name
chloride channel regulator 2
Introduction
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N-and C-terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines.
Entrez Gene ID
9635
UniProt ID
Q9UQC9
Alternative Names
Chloride Channel Accessory 2; Chloride Channel, Calcium Activated, Family Member 2; Calcium-Activated Chloride Channel Protein 3; CaCC-3; CACC3; Calcium-Activated Chloride Channel Family Member 2; CLCA Family Member 2, Chloride Channel Regulator; Calcium-Activated Chloride Channel Regulator 2
Function
Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
Biological Process
Cell adhesion Source: UniProtKB-KW
Chloride transport Source: Ensembl
Ion transmembrane transport Source: Reactome
Cellular Location
Cell membrane; Basal cell membrane; Cell junction
Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Remains associated to the 35 kDa form until an unidentified event triggers the release.
Topology
Extracellular: 32-901
Helical: 902-922
Cytoplasmic: 923-943
PTM
The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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