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Mouse Anti-CKB Recombinant Antibody (CBYY-C2846) (CBMAB-C4287-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYY-C2846
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
His-tagged CKB protein.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Creatine Kinase B
Entrez Gene ID
Human1152
Mouse12709
Rat24264
UniProt ID
HumanP12277
MouseQ04447
RatP07335
Alternative Names
C-Reactive Protein; C-Reactive Protein, Pentraxin-Related; Pentraxin 1; PTX1;
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Biological Process
Cellular chloride ion homeostasis Source: Ensembl
Cerebellum development Source: Ensembl
Creatine metabolic process Source: Reactome
Phosphocreatine biosynthetic process Source: GO_Central
Substantia nigra development Source: UniProtKB
Cellular Location
Cytoplasm
More Infomation

Rahbani, J. F., Roesler, A., Hussain, M. F., Samborska, B., Dykstra, C. B., Tsai, L., ... & Kazak, L. (2021). Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature, 590(7846), 480-485.

Krutilina, R. I., Playa, H. C., Brooks, D. L., Schwab, L. P., Parke, D. N., Oluwalana, D., ... & Seagroves, T. N. (2021). HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, and blocking creatine kinase activity with cyclocreatine impairs invasion and improves the efficacy of conventional chemotherapies. bioRxiv.

Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., ... & Linse, S. (2021). Calmodulin complexes with brain and muscle creatine kinase peptides. Current Research in Structural Biology, 3, 121-132.

Jeong, Y. J., Park, S. W., Seo, M. K., Kim, S. J., Lee, W. H., Kim, M., ... & Seog, D. H. (2021). The Heterotrimeric Kinesin-2 Family Member KIF3A Directly Binds to Creatine Kinase B. Journal of Life Science, 31(3), 257-265.

Vallecillo, R. (2021). Determining the Role of Brain-Type Creatine Kinase in the Lungs During Asthma.

Sun, X. B., Lim, G. T., Lee, J., Wan, J. X., Lin, H. Z., Yang, J. M., ... & Park, Y. D. (2018). Effects of osmolytes on the refolding of recombinant Pelodiscus sinensis brain-type creatine kinase. Process Biochemistry, 68, 83-92.

Hwang, J. H. (2017). Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea. Metabolic brain disease, 32(3), 735-742.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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