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Mouse Anti-CHAC1 Recombinant Antibody (CBYY-C1950) (CBMAB-C3388-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C1950
Antibody Isotype
IgG2a, κ
Application
WB, IHC, IF

Basic Information

Immunogen
Amino acids 1-222 (full-length) of rat Botch1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
1 mM sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1
Entrez Gene ID
79094
UniProt ID
Q9BUX1
Alternative Names
HP10433, TIG2
Function
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623).
Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178).
Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Biological Process
Glutathione biosynthetic process Source: Reactome
Glutathione catabolic process Source: GO_Central
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
Negative regulation of Notch signaling pathway Source: UniProtKB
Negative regulation of protein processing Source: UniProtKB
Neurogenesis Source: UniProtKB
Notch signaling pathway Source: UniProtKB-KW
Response to unfolded protein Source: UniProtKB-KW
Cellular Location
Cytosol; Trans-Golgi network
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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