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Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY)


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Published Data
CBMAB-H0940-FY-1
Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY) in WB
BeWo cells were mock-treated or treated with EGF/CASVY (i.e., cultured in incomplete or complete TS medium) for 24 h for analysis of trophoblast stemness or differentiation gene expression. AXIN2, a direct target of WNT signaling, was used as a control. Arrow and arrowhead denote the ΔNp63α band and a non-specific band, respectively. ...View More
Wang, L. J., Chen, C. P., Lee, Y. S., Ng, P. S., Chang, G. D., Pao, Y. H., ... & Chen, H. (2022). Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation. Nature Communications, 13(1), 1626.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-H0940-FY-2
Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY) in IF
Expression of ΔNp63α, GCM1, and hCGβ in ITGA6-positive term CTBs in response to EGF/CASVY treatment and withdrawal. Note that E-cadherin staining reveals formation of hCGβ-expressing syncytium after EGF/CASVY withdrawal. ...View More
Wang, L. J., Chen, C. P., Lee, Y. S., Ng, P. S., Chang, G. D., Pao, Y. H., ... & Chen, H. (2022). Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation. Nature Communications, 13(1), 1626.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-H0940-FY-3
Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY) in IHC
NOD-SCID mice were subcutaneously injected with TSTerm#2 (a, b) or TS#2GCM1-KO#6 (c) cells for 10 days. Sections of TSTerm#2 and TS#2GCM1-KO#6 cell-derived lesions were subjected to hematoxylin and eosin (HE) staining and immunostaining of CK7, hCGβ, and HLA-G. Scale bar, 100 μm. ...View More
Wang, L. J., Chen, C. P., Lee, Y. S., Ng, P. S., Chang, G. D., Pao, Y. H., ... & Chen, H. (2022). Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation. Nature Communications, 13(1), 1626.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-H0940-FY-4
Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY) in WB
Western blot analysis of β-hCG expression in normal mammary gland, xenograft tumor developed using MDAMB-231 cells and mouse mammary tumor of BRCA1 floxed conditional knockout mouse tissue generated from WAP-Cre; BRCA1KO/CO and MMTV-Cre; BRCA1KO/CO animals. ...View More
Sengodan, S. K., Nadhan, R., Nair, R. S., Hemalatha, S. K., Somasundaram, V., Sushama, R. R., ... & Srinivas, P. (2017). BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer. Oncogenesis, 6(9), e376-e376.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-H0940-FY-5
Mouse Anti-CGB3 Monoclonal Antibody (CBFYH-2945) (CBMAB-H0940-FY) in IF
Immunoflourescence of Vimentin in HCC1937 control vector transfected (HCC1937 C.vec), HCC1937 β-hCG transfected (HCC1937 β), HCC1937/wt BRCA1 control vector transfected (HCC1937/wt BRCA1 C.vec) and HCC1937/wt BRCA1 β-hCG transfected (HCC1937/wt BRCA1 β) cells. DAPI was used as nuclear stain. ...View More
Sengodan, S. K., Nadhan, R., Nair, R. S., Hemalatha, S. K., Somasundaram, V., Sushama, R. R., ... & Srinivas, P. (2017). BRCA1 regulation on β-hCG: a mechanism for tumorigenicity in BRCA1 defective breast cancer. Oncogenesis, 6(9), e376-e376.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2945
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
C-terminus of the Choriogonadotropin β precursor of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chorionic Gonadotropin, beta polypeptide Peptide 1
Introduction
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.
Entrez Gene ID
1082
UniProt ID
P0DN86
Alternative Names
Chorionic Gonadotropin Beta Subunit 3; Chorionic Gonadotropin, Beta Polypeptide; Chorionic Gonadotropin Chain Beta; CG-Beta; CGB; Chorionic Gonadotropin Beta 3 Subunit; Chorionic Gonadotrophin Chain Beta; Choriogonadotropin Subunit Beta 3
Function
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Biological Process
Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Female gamete generation Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Hormone-mediated signaling pathway Source: GO_Central
Peptide hormone processing Source: Reactome
Regulation of transcription by RNA polymerase II Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

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