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Mouse Anti-CEACAM8 Recombinant Antibody (CBXC-1352) (CBMAB-C1621-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXC-1352
Antibody Isotype
IgM, κ
Application
FC, IHC, IF

Basic Information

Immunogen
Human peripheral blood cells.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1:10-1:500
FC1 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8
Introduction
CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is CEACAM6.
Entrez Gene ID
1088
UniProt ID
P31997
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8; Non-Specific Cross-Reacting Antigen NCA-95; Carcinoembryonic Antigen CGM6; CD67 Antigen; CGM6;
Function
Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Heterophilic interaction with CEACAM8 oCcurs in activated neutrophils (PubMed:8776764).
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immune response Source: ProtInc
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Cellular Location
Cell membrane; Cell surface
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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