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Rabbit Anti-CD7 Recombinant Antibody (CBFYC-1406) (CBMAB-C1464-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-1406
Antibody Isotype
IgG
Application
ELISA, IHC-P

Basic Information

Immunogen
Recombinant Human CD7 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000
IHC-P1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-150

Target

Full Name
CD7 Molecule
Introduction
CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Pityriasis Lichenoides Et Varioliformis Acuta and T-Cell Leukemia. Among its related pathways are Hematopoietic cell lineage and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include receptor activity.
Entrez Gene ID
12516
UniProt ID
P50283
Alternative Names
CD7 Molecule; T-Cell Leukemia Antigen; T-Cell Surface Antigen Leu-9; T-Cell Antigen CD7; CD7 Antigen (P41); P41 Protein;
Biological Process
Adaptive immune response Source: UniProtKB-KW
Immune response Source: UniProtKB
T cell activation Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 26-180
Helical: 181-201
Cytoplasmic: 202-240
More Infomation

Li, S., Wang, X., Yuan, Z., Liu, L., Luo, L., Li, Y., ... & Wang, S. (2021). Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management. Clinical Cancer Research, 27(5), 1242-1246.

Kim, M. Y., Cooper, M. L., Jacobs, M. T., Ritchey, J. K., Hollaway, J., Fehniger, T. A., & DiPersio, J. F. (2021). CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI insight, 6(16).

Zhang, J., Jain, A., Milhas, S., Williamson, D. J., Mysliwy, J., Lodge, A., ... & Rabbitts, T. H. (2021). An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leukemia Research, 108, 106626.

Gomes-Silva, D., Atilla, E., Atilla, P. A., Mo, F., Tashiro, H., Srinivasan, M., ... & Mamonkin, M. (2019). CD7 CAR T cells for the therapy of acute myeloid leukemia. Molecular Therapy, 27(1), 272-280.

You, F., Wang, Y., Jiang, L., Zhu, X., Chen, D., Yuan, L., ... & Yang, L. (2019). A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia. American journal of cancer research, 9(1), 64.

Mayer, K. E., Mall, S., Yusufi, N., Gosmann, D., Steiger, K., Russelli, L., ... & Krackhardt, A. M. (2018). T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target. Theranostics, 8(21), 6070.

Gomes-Silva, D., Srinivasan, M., Sharma, S., Lee, C. M., Wagner, D. L., Davis, T. H., ... & Mamonkin, M. (2017). CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood, The Journal of the American Society of Hematology, 130(3), 285-296.

Yu, Y., Li, J., Zhu, X., Tang, X., Bao, Y., Sun, X., ... & Yang, L. (2017). Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. International journal of nanomedicine, 12, 1969.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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