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Mouse Anti-CD38 Recombinant Antibody (AT13/5) (CBMAB-C0449-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
AT13/5
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, FC

Basic Information

Immunogen
NAMALWA Burkitt's lymphoma cell line of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
CD38 Molecule
Introduction
CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Richter's Syndrome and Leukemia, Chronic Lymphocytic. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.
Entrez Gene ID
952
UniProt ID
P28907
Alternative Names
CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase;
Function
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Biological Process
Apoptotic signaling pathway Source: ProtInc
Artery smooth muscle contraction Source: Ensembl
B cell receptor signaling pathway Source: UniProtKB
Female pregnancy Source: Ensembl
Long-term synaptic depression Source: Ensembl
NAD metabolic process Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of bone resorption Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of cell growth Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of vasoconstriction Source: Ensembl
Response to drug Source: UniProtKB
Response to estradiol Source: Ensembl
Response to hydroperoxide Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to progesterone Source: Ensembl
Response to retinoic acid Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Membrane
Topology
Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-300
More Infomation

García-Guerrero, E., Götz, R., Doose, S., Sauer, M., Rodríguez-Gil, A., Nerreter, T., ... & Danhof, S. (2021). Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia, 35(1), 201-214.

Piedra-Quintero, Z. L., Wilson, Z., Nava, P., & Guerau-de-Arellano, M. (2020). CD38: an immunomodulatory molecule in inflammation and autoimmunity. Frontiers in immunology, 11, 3111.

Katsuyama, E., Suarez-Fueyo, A., Bradley, S. J., Mizui, M., Marin, A. V., Mulki, L., ... & Tsokos, G. C. (2020). The CD38/NAD/SIRTUIN1/EZH2 axis mitigates cytotoxic CD8 T cell function and identifies patients with SLE prone to infections. Cell reports, 30(1), 112-123.

Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., ... & Lopatina, O. (2020). CD38, CD157, and RAGE as molecular determinants for social behavior. Cells, 9(1), 62.

Glaría, E., & Valledor, A. F. (2020). Roles of CD38 in the Immune Response to Infection. Cells, 9(1), 228.

Ning, L., Shan, G., Sun, Z., Zhang, F., Xu, C., Lou, X., ... & Xu, G. (2019). Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease. BioMed research international, 2019.

Morandi, F., Airoldi, I., Marimpietri, D., Bracci, C., Faini, A. C., & Gramignoli, R. (2019). CD38, a receptor with multifunctional activities: from modulatory functions on regulatory cell subsets and extracellular vesicles, to a target for therapeutic strategies. Cells, 8(12), 1527.

Malavasi, F., & Faini, A. C. (2019). Mechanism of action of a new anti-CD38 antibody: enhancing myeloma immunotherapy. Clinical Cancer Research, 25(10), 2946-2948.

van de Donk, N. W., Richardson, P. G., & Malavasi, F. (2018). CD38 antibodies in multiple myeloma: back to the future. Blood, The Journal of the American Society of Hematology, 131(1), 13-29.

Van De Donk, N. W., & Usmani, S. Z. (2018). CD38 antibodies in multiple myeloma: mechanisms of action and modes of resistance. Frontiers in immunology, 9, 2134.

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For research use only. Not intended for any clinical use.

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