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Rat Anti-CD200 Recombinant Antibody (OX90) (CBMAB-O0785-CQ)


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Published Data
CBMAB-O0785-CQ-1
Rat Anti-CD200 Recombinant Antibody (OX90) (CBMAB-O0785-CQ) in IF
Representative immunofluorescence images of CD200 in LNs from naïve and inflamed conditions. Arrowheads: SCS floor, scale bar 50 µm. ...View More
Sibler, E., He, Y., Ducoli, L., Keller, N., Fujimoto, N., Dieterich, L. C., & Detmar, M. (2021). Single-cell transcriptional heterogeneity of lymphatic endothelial cells in normal and inflamed murine lymph nodes. Cells, 10(6), 1371. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Rat
Specificity
Mouse
Clone
OX90
Antibody Isotype
IgG2a, κ
Application
IF, FC, IHC, Blocking

Basic Information

Immunogen
Fusion protein consisting of mouse CD200 (extracellular region) and rat CD4 (domains 3 and 4).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD200 Molecule
Introduction
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity.
Entrez Gene ID
17470
UniProt ID
O54901
Alternative Names
CD200 Molecule; CD200 Antigen; Antigen Identified By Monoclonal Antibody MRC OX-2; MOX1; MOX2; OX-2 Membrane Glycoprotein; OX-2; MRC;
Function
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Biological Process
Cell-cell adhesion Source: ARUK-UCL
Heterotypic cell-cell adhesion Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of leukocyte activation Source: ARUK-UCL
Negative regulation of macrophage activation Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of matrix metallopeptidase secretion Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Positive regulation of arginase activity Source: ARUK-UCL
Positive regulation of CREB transcription factor activity Source: ARUK-UCL
Positive regulation of protein-glutamine gamma-glutamyltransferase activity Source: ARUK-UCL
Positive regulation of transforming growth factor beta production Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 31-232
Helical: 233-259
Cytoplasmic: 260-278
More Infomation

Liu, J. Q., Hu, A., Zhu, J., Yu, J., Talebian, F., & Bai, X. F. (2020). CD200-CD200R Pathway in the regulation of tumor immune microenvironment and immunotherapy. Tumor Microenvironment, 155-165.

Ismail, A. A., Donia, H. M., Ghatesh, H. M., & Farid, C. I. (2020). CD200/CD200 receptor axis in psoriasis vulgaris. PloS one, 15(3), e0230621.

Estep, R. D., Govindan, A. N., Fitzpatrick, K., Blair, T. C., Rezaee, S. R., Blackbourn, D. J., & Wong, S. W. (2020). Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation. Journal of virology, 95(5), e01654-20.

Weng, L. C., Hou, S. H., Lei, S. T., Peng, H. Y., Li, M. Q., & Zhao, D. (2020). Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis. Journal of reproductive immunology, 138, 103090.

Manich, G., Recasens, M., Valente, T., Almolda, B., González, B., & Castellano, B. (2019). Role of the CD200-CD200R axis during homeostasis and neuroinflammation. Neuroscience, 405, 118-136.

Olin, M. R., Ampudia-Mesias, E., Pennell, C. A., Sarver, A., Chen, C. C., Moertel, C. L., ... & Pluhar, G. E. (2019). Treatment combining CD200 immune checkpoint inhibitor and tumor-lysate vaccination after surgery for pet dogs with high-grade glioma. Cancers, 11(2), 137.

Rexin, P., Tauchert, A., Haenze, J., Heers, H., Schmidt, A., Hofmann, R., & Hegele, A. (2018). The immune checkpoint molecule CD200 is associated with tumor grading and metastasis in bladder cancer. Anticancer research, 38(5), 2749-2754.

Chen, Z., Kapus, A., Khatri, I., Kos, O., Zhu, F., & Gorczynski, R. M. (2018). Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment. Leukemia research, 69, 72-80.

Nouri, F., Sadeghpour, H., Heidari, R., & Dehshahri, A. (2017). Preparation, characterization, and transfection efficiency of low molecular weight polyethylenimine-based nanoparticles for delivery of the plasmid encoding CD200 gene. International journal of nanomedicine, 12, 5557.

Gorczynski, R. M., & Zhu, F. (2017). Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200. Cancer management and research, 9, 601.

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For research use only. Not intended for any clinical use.

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