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Mouse Anti-CCT2 Recombinant Antibody (CBFYC-1095) (CBMAB-C1152-FY)


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Published Data
CBMAB-C1152-FY-1
Mouse Anti-CCT2 Recombinant Antibody (CBFYC-1095) (CBMAB-C1152-FY) in IF
Neuro-2a cells were transfected with an expression vector for HTTQ78-GFP. At 48 h after transfection, cells were fixed, immunostained with anti-PFD2, anti-PFD5, anti-CCTβ, anti-HSC70, and anti-GFP antibodies, and then reacted with an Alexa Fluor 594-conjugated anti-IgG antibody. ...View More
Tashiro, E., Zako, T., Muto, H., Itoo, Y., Sörgjerd, K., Terada, N., ... & Ariga, H. (2013). Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation. Journal of Biological Chemistry, 288(27), 19958-19972. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Frrog
Clone
CBFYC-1095
Antibody Isotype
IgG2a, κ
Application
IHC-P, IF, IP, WB

Basic Information

Immunogen
Ovalbumin-conjugate synthetic peptide RKRVPDHHPC.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Frrog
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chaperonin containing TCP1, subunit 2 (beta)
Introduction
CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include Gallbladder Adenocarcinoma and Adenosquamous Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and unfolded protein binding.
Entrez Gene ID
Human10576
Mouse12461
Rat299809
Monkey717182
Cattle505313
Dog474445
Frog448434
Hamster100759253
Horse100059914
Pig100157776
Bat118623927
Zebrafish192326
UniProt ID
HumanP78371
MouseP80314
RatQ5XIM9
MonkeyF6PJP5
CattleQ3ZBH0
DogF6V0D8
FrogF6YJW1
HamsterP86245
HorseA0A3Q2L8X2
PigF6Q936
BatG1PBC0
ZebrafishQ6PBW6
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Chaperone-mediated protein complex assembly Source: MGI
Chaperone mediated protein folding independent of cofactor Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
scaRNA localization to Cajal body Source: BHF-UCL
Toxin transport Source: Ensembl
Cellular Location
Cytoplasm
More Infomation

Ghozlan, H., Showalter, A., Lee, E., Zhu, X., & Khaled, A. R. (2021). Chaperonin-Containing TCP1 complex (CCT) promotes breast cancer growth through correlations with key cell cycle regulators. Frontiers in oncology, 11.

Li, W., Liu, J., & Zhao, H. (2021). Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma. Frontiers in genetics, 12, 502.

Ghozlan, H. H., Showalter, A., & Khaled, A. R. (2021). Chaperonin-Containing TCP1 complex (CCT) promotes breast cancer by targeting key cell cycle regulators.

Cox, A., Martini, A., Lee, E., Moroose, R., Khaled, A., & Khaled, A. R. (2021). Using chaperonin containing TCP1 as a marker to track clinically relevant circulating tumor cells.

Liu, Q., Qi, Y., Kong, X., Wang, X., Zhang, W., Zhai, J., ... & Wang, J. (2021). Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer. Frontiers in oncology, 11.

Showalter, A. E., Martini, A. C., Nierenberg, D., Hosang, K., Fahmi, N. A., Gopalan, P., ... & Khaled, A. R. (2020). Investigating chaperonin-containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Scientific reports, 10(1), 1-14.

Hallal, S., Russell, B. P., Wei, H., Lee, M. Y. T., Toon, C. W., Sy, J., ... & Kaufman, K. L. (2019). Extracellular vesicles from neurosurgical aspirates identifies chaperonin containing TCP1 subunit 6A as a potential glioblastoma biomarker with prognostic significance. Proteomics, 19(1-2), 1800157.

Carr, A. C., Khaled, A. S., Bassiouni, R., Flores, O., Nierenberg, D., Bhatti, H., ... & Khaled, A. R. (2017). Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer. Oncotarget, 8(66), 110273.

Li, L. J., Zhang, L. S., Han, Z. J., He, Z. Y., Chen, H., & Li, Y. M. (2017). Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth. Oncotarget, 8(67), 111470.

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For research use only. Not intended for any clinical use.

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