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Armenian Hamster Anti-CCL2 Recombinant Antibody (2H5) (CBMAB-1117-LY)

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Summary

Host Animal
Armenian Hamster
Specificity
Human, Mouse, Rat
Clone
2H5
Antibody Isotype
IgG1, κ
Application
Neutralization, In vivo, IHC

Basic Information

Immunogen
CHO-expressed mouse MCP-1.
Host Species
Armenian Hamster
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCL2 (MCP-1)
Entrez Gene ID
Human6347
Mouse20296
Rat24770
UniProt ID
HumanP13500
MouseP10148
RatP14844
Alternative Names
MCP-1
More Infomation

Dommel, S., & Blüher, M. (2021). Does CC Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?. International Journal of Molecular Sciences, 22(3), 1500.

Schettini, I. V. G., Faria, D. V., Nogueira, L. S., Otoni, A., Silva, A. C. S., & Rios, D. R. A. (2021). Renin angiotensin system molecules and chemokine (CC motif) ligand 2 (CCL2) in chronic kidney disease patients. Brazilian Journal of Nephrology.

Li, M., Chen, Y., Zhang, Y., Li, D., & Liu, J. (2020). Correlation between monocyte chemoattractant protein-1/chemokine (CC motif) ligand 2 and coronary plaque characteristics. Experimental Biology and Medicine, 245(15), 1335-1343.

Iwamoto, H., Izumi, K., & Mizokami, A. (2020). Is the CC Motif Ligand 2–CC Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis?. International Journal of Molecular Sciences, 21(23), 9328.

Hernández-Aguilera, A., Fibla, M., Cabré, N., Luciano-Mateo, F., Camps, J., Fernández-Arroyo, S., ... & Joven, J. (2020). Chemokine (CC motif) ligand 2 and coronary artery disease: tissue expression of functional and atypical receptors. Cytokine, 126, 154923.

Luciano-Mateo, F., Cabré, N., Baiges-Gaya, G., Fernández-Arroyo, S., Hernández-Aguilera, A., Rodríguez-Tomàs, E. E., ... & Joven, J. (2020). Systemic overexpression of CC motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging. Aging (Albany NY), 12(20), 20001.

Li, L., Lou, W., Li, H., & Zhu, Y. (2020). Upregulated CC motif chemokine ligand 2 promotes ischemic stroke via chemokine signaling pathway. Annals of Vascular Surgery, 68, 476-486.

Kimura, A., Yoshikura, N., Hayashi, Y., & Inuzuka, T. (2018). Cerebrospinal fluid CC motif chemokine ligand 2 correlates with brain atrophy and cognitive impairment in Alzheimer’s disease. Journal of Alzheimer's Disease, 61(2), 581-588.

Yoshida, H., Imaizumi, T., Matsumiya, T., Seya, K., Kawaguchi, S., & Tanaka, H. (2018). Gnetin C suppresses double-stranded RNA-induced CC motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway. Biomedical Research, 39(5), 231-240.

Lai, C., Wang, K., Zhao, Z., Zhang, L., Gu, H., Yang, P., & Wang, X. (2017). CC motif chemokine ligand 2 (CCL2) mediates acute lung injury induced by lethal influenza H7N9 virus. Frontiers in microbiology, 8, 587.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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