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Mouse Anti-CCDC36 Recombinant Antibody (2D11) (CBMAB-C4858-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D11
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human CCDC36 produced in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coiled-Coil Domain Containing 36
Introduction
CCDC36 (Coiled-Coil Domain Containing 36) is a Protein Coding gene.
Entrez Gene ID
339834
UniProt ID
Q8IYA8
Alternative Names
Coiled-Coil Domain Containing 36; Cancer/Testis Antigen 74; Coiled-Coil Domain-Containing Protein 36; CT74; Interactor Of HORMAD1 Protein 1; IHO1;
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
Biological Process
DNA recombination Source: UniProtKB-KW
Homologous chromosome pairing at meiosis Source: UniProtKB
Meiotic DNA double-strand break formation Source: UniProtKB
Oogenesis Source: UniProtKB
Regulation of homologous chromosome segregation Source: UniProtKB
Spermatogenesis Source: UniProtKB
Cellular Location
Chromosome. Specifically localizes to unsynapsed chromosomal regions during meiosis.
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For research use only. Not intended for any clinical use.

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