Mouse Anti-CBLN2 Recombinant Antibody (704323) (CBMAB-C8407-LY)

Name: Mouse Anti-CBLN2 Recombinant Antibody (704323)
SKU: CBMAB-C8407-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

704323

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Cerebellin-2 Arg50-Leu224.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cerebellin 2 Precursor

Introduction

CBLN2 (Cerebellin 2 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN1.

Entrez Gene ID

147381

UniProt ID

Q8IUK8

Alternative Names

Cerebellin 2 Precursor; Cerebellin-2;

Function

Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity).
Essential for long-term maintenance but not establishment of excitatory synapses (By similarity).

Biological Process

Maintenance of synapse structure Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl
Regulation of presynapse assembly Source: Ensembl
Spontaneous synaptic transmission Source: UniProtKB
Synapse organization Source: UniProtKB

Cellular Location

Secreted

More Infomation

References

Seigneur, E., Wang, J., Dai, J., Polepalli, J., & Südhof, T. C. (2021). Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular Psychiatry, 1-13.

Shibata, M., Pattabiraman, K., Muchnik, S. K., Kaur, N., Morozov, Y. M., Cheng, X., ... & Sestan, N. (2021). Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature, 598(7881), 489-494.

Sandor, K., Krishnan, S., Agalave, N. M., Krock, E., Salcido, J. V., Fernandez-Zafra, T., ... & Kultima, K. (2018). Spinal injection of newly identified cerebellin-1 and cerebellin-2 peptides induce mechanical hypersensitivity in mice. Neuropeptides, 69, 53-59.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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