Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918) (CBMAB-C2355-YY)

Name: Mouse Anti-CAMKK1 Recombinant Antibody (CBYY-C0918)
SKU: CBMAB-C2355-YY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C0918

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

CAMKK1 (AAH31647.1, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Calcium/Calmodulin Dependent Protein Kinase Kinase 1

Entrez Gene ID

84254

UniProt ID

Q8N5S9

Alternative Names

Caspase Recruitment Domain Family Member 14; CARD-Containing MAGUK Protein 2; CARMA2; Caspase Recruitment Domain-Containing Protein 14; Caspase Recruitment Domain Family, Member 14; Bcl10-Interacting Maguk Protein 2; Psoriasis Susceptibility 2;

Function

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Biological Process

Chemical synaptic transmission Source: Reactome
Intracellular signal transduction Source: GO_Central
Positive regulation of protein kinase activity Source: GO_Central

Cellular Location

Cytoplasm; Nucleus

PTM

Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).

More Infomation

References

Beghi, S., Cavaliere, F., Manfredini, M., Ferrarese, S., Corazzari, C., Beghi, C., & Buschini, A. (2021). Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases. Bioscience Reports, 41(7), BSR20210326.

Mikulů, M. (2020). Studium struktury komplexů proteinu 14-3-3 s CaMKK1 a CaMKK1: Ca2+/CaM.

Prajisha, J., Biswal, J., & Jeyakanthan, J. (2020). Discovery of potent Camkk1 kinase inhibitors through e-pharmacophore and molecular screening approaches. Journal of Biomolecular Structure and Dynamics, 1-17.

AdS, S., Couñago, R. M., Godoi, P. H. C., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

da Silva Santiago, A., Couñago, R. M., Ramos, P. Z., Godoi, P. H., Massirer, K. B., Gileadi, O., & Elkins, J. M. (2018). Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Scientific reports, 8(1), 1-10.

Dong, F., Patnaik, S., Duan, Z. H., Kiedrowski, M., Penn, M. S., & Mayorga, M. E. (2017). A novel role for CAMKK1 in the regulation of the mesenchymal stem cell secretome. Stem cells translational medicine, 6(9), 1759-1766.

Wang, J., Lan, X., Jiang, S., Ma, Y., Zhang, S., Li, Y., ... & Lan, H. (2017). CaMKK1 from Chenopodium album positively regulates salt and drought tolerance in transgenic tobacco. Plant Cell, Tissue and Organ Culture (PCTOC), 130(1), 209-225.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CAMKK1 Matched Antibody Pair (176)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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