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Mouse Anti-CABP4 Recombinant Antibody (CBXC-0035) (CBMAB-C5189-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0035
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CABP4 produced in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium binding protein 4
Introduction
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
57010
UniProt ID
P57796
Alternative Names
Calcium Binding Protein 4; Calcium-Binding Protein 4; CSNB2B; CaBP4; CRSD;
Function
Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).
Biological Process
Photoreceptor cell morphogenesis Source: Ensembl
Phototransduction Source: Ensembl
Retinal bipolar neuron differentiation Source: Ensembl
Retinal cone cell development Source: Ensembl
Signal transduction Source: UniProtKB
Visual perception Source: UniProtKB
Cellular Location
Cytoplasm; Presynapse. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
Involvement in disease
Cone-rod synaptic disorder, congenital non-progressive (CRSD): A non-progressive retinal disorder characterized by stable low vision, nystagmus, photophobia, a normal or near-normal fundus appearance, and no night blindness.
PTM
Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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