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Mouse Anti-BPNT1 Recombinant Antibody (CBYY-1665) (CBMAB-2014-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-1665
Antibody Isotype
IgG1, κ
Application
E, IF, IP, WB

Basic Information

Immunogen
Amino acids 64-89 within an internal region of BPNT1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
3'(2'), 5'-bisphosphate nucleotidase 1
Introduction
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
Entrez Gene ID
10380
UniProt ID
O95861
Alternative Names
3'(2'), 5'-Bisphosphate Nucleotidase 1; 3(2), 5-Bisphosphate Nucleotidase 1; Bisphosphate 3-Nucleotidase 1; EC 3.1.3.7; PIP; 3(2),5-Bisphosphate Nucleotidase 1; Testicular Tissue Protein Li 29;
Function
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins1P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
Inositol phosphate dephosphorylation Source: InterPro
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Phosphatidylinositol phosphorylation Source: InterPro
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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