Mouse Anti-BPIFA2 Recombinant Antibody (CBYY-0739) (CBMAB-0742-YY)

Name: Mouse Anti-BPIFA2 Recombinant Antibody (CBYY-0739)
SKU: CBMAB-0742-YY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-0739

Antibody Isotype

IgG1

Application

E, FC, WB

Basic Information

Immunogen

Purified recombinant fragment of human Splunc2 expressed in E. coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000
FC	1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.03% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-Terminus

Target

Full Name

BPI Fold Containing Family A Member 2

Introduction

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

140683

UniProt ID

Q96DR5

Alternative Names

BPI Fold Containing Family A Member 2; Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2; Parotid Secretory Protein; C20orf70; SPLUNC2; PSP; BPI Fold-Containing Family A Member 2; Chromosome 20 Open Reading Frame 70; BA49G10.1;

Function

Has strong antibacterial activity against P. aeruginosa.

Biological Process

Antimicrobial humoral response Source: Reactome
Defense response to bacterium Source: UniProtKB-KW

Cellular Location

Secreted

More Infomation

References

Nandula, S. R., Huxford, I., Wheeler, T. T., Aparicio, C., & Gorr, S. U. (2020). The parotid secretory protein BPIFA2 is a salivary surfactant that affects lipopolysaccharide action. Experimental physiology, 105(8), 1280-1292.

Gorr, S. U., & Nevels, M. (2020). The salivary protein BPIFA2 differentially regulates sodium preference and blood pressure in male and female mice. Experimental Results, 1.

Sallustio, F., Stasi, A., Curci, C., Divella, C., Picerno, A., Franzin, R., ... & Gesualdo, L. (2019). Renal progenitor cells revert LPS‐induced endothelial‐to‐mesenchymal transition by secreting CXCL6, SAA4, and BPIFA2 antiseptic peptides. The FASEB Journal, 33(10), 10753-10766.

Honore, P. M., De Bels, D., & Spapen, H. D. (2018). BPI fold-containing family a member 2 as a biomarker of acute kidney injury—close but no (clinical) cigar?. Annals of translational medicine, 6(10).

Kota, S. K., Pernicone, E., Leaf, D. E., Stillman, I. E., Waikar, S. S., & Kota, S. B. (2017). BPI fold-containing family a member 2/parotid secretory protein is an early biomarker of AKI. Journal of the American Society of Nephrology, 28(12), 3473-3478.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-BPIFA2 Recombinant Antibody (2B4F5)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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