Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-BLVRB Recombinant Antibody (CBYY-1655) (CBMAB-2004-YY)


See all BLVRB antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1655
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant Human BLVRB / biliverdin reductase B protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
biliverdin reductase B (flavin reductase (NADPH))
Introduction
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).
Entrez Gene ID
645
UniProt ID
P30043
Alternative Names
Biliverdin Reductase B; Short Chain Dehydrogenase/Reductase Family 43U, Member 1; Biliverdin-IX Beta-Reductase; Green Heme-Binding Protein; NADPH-Dependent Diaphorase; NADPH-Flavin Reductase; BVR-B; GHBP; FLR; FR; Biliverdin Reductase B (Flavin Reductase (NADPH));
Function
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe3+ iron to Fe2+ in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Biological Process
Heme catabolic process Source: UniProtKB
Cellular Location
Cytoplasm
More Infomation

Eisenmesser, E., Redzic, J. S., Duff, M. R., Blue, A., Pitts, T., & Agarwal, P. (2021). Modulating enzyme function via dynamic allostery within biliverdin reductase B. Frontiers in molecular biosciences, 8, 429.

Duff Jr, M. R., Redzic, J. S., Ryan, L. P., Paukovich, N., Zhao, R., Nix, J. C., ... & Eisenmesser, E. Z. (2020). Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family. The Journal of Biochemistry, 168(2), 191-202.

Lok, C. N., Lai, Y. T., & Fung, Y. M. (2019). BILIVERDIN REDUCTASE B/FLAVIN REDUCTASE (BLVRB/FLR) EXHIBITS HEME-REGULATED, NADPH-DEPENDENT REDUCTASE ACTIVITY AND CONFERS CYTOPROTECTION IN DEVELOPING ERYTHROID CELLS. Experimental Hematology, 76, S76.

Nesbitt, N. M., Zheng, X., Li, Z., Manso, J. A., Yen, W. Y., Malone, L. E., ... & Bahou, W. F. (2018). In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency. Journal of Biological Chemistry, 293(15), 5431-5446.

Paukovich, N., Xue, M., Elder, J. R., Redzic, J. S., Blue, A., Pike, H., ... & Eisenmesser, E. Z. (2018). Biliverdin reductase B dynamics are coupled to coenzyme binding. Journal of molecular biology, 430(18), 3234-3250.

Matic, L. P., Jesus Iglesias, M., Vesterlund, M., Lengquist, M., Hong, M. G., Saieed, S., ... & Hedin, U. (2018). Novel multiomics profiling of human carotid atherosclerotic plaques and plasma reveals biliverdin reductase B as a marker of intraplaque hemorrhage. JACC: Basic to Translational Science, 3(4), 464-480.

Chu, W. T., Nesbitt, N. M., Gnatenko, D. V., Li, Z., Zhang, B., Seeliger, M. A., ... & Wang, J. (2017). Enzymatic activity and thermodynamic stability of biliverdin IXβ reductase are maintained by an active site serine. Chemistry (Weinheim an der Bergstrasse, Germany), 23(8), 1891.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BLVRB Recombinant Antibody (CBYY-1655)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry