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Mouse Anti-BAMBI Recombinant Antibody (CBYY-2032) (CBMAB-2381-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-2032
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 21-152 of human BAMBI produced in E.coli.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
Introduction
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
Entrez Gene ID
25805
UniProt ID
Q13145
Alternative Names
BMP And Activin Membrane Bovineund Inhibitor; Putative Transmembrane Protein NMA; Non-Metastatic Gene A Protein; NMA; BMP And Activin Membrane-Bovineund Inhibitor Homolog (Xenopus Laevis); BMP And Activin Membrane-Bovineund Inhibitor Homolog;
Function
Negatively regulates TGF-beta signaling.
Biological Process
Cell migration Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: ARUK-UCL
Negative regulation of osteoblast differentiation Source: ARUK-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of cell shape Source: BHF-UCL
Transforming growth factor beta receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 21-152 aa
Helical: 153-173 aa
Cytoplasmic: 174-260 aa
More Infomation

Chen, X., Zhao, C., Xu, Y., Huang, K., Wang, Y., Wang, X., ... & Yu, T. (2021). Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI) deletion promotes adipogenesis by accelerating ROS production. Journal of Biological Chemistry, 296.

Nangaku, M. (2020). Schlöndorff and Lee revealed crosstalk between glomerular cells and a role of BAMBI in diabetic kidney disease. Kidney International, 98(3), 539-541.

Alvarez, P., Augustín, J. J., Tamayo, E., Iglesias, M., Acinas, O., Mendiguren, M. A., ... & Merino, R. (2020). Therapeutic Effects of Anti–Bone Morphogenetic Protein and Activin Membrane‐Bound Inhibitor Treatment in Psoriasis and Arthritis. Arthritis & Rheumatology, 72(9), 1547-1558.

Yao, X., Yu, T., Xi, F., Xu, Y., Ma, L., Pan, X., ... & Xie, L. (2019). BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration. Biochemical and biophysical research communications, 509(1), 125-132.

Wang, D., Chen, X., & Zhang, R. (2018). BAMBI promotes macrophage proliferation and differentiation in gliomas. Molecular medicine reports, 17(3), 3960-3966.

Hernandez, H., Millar, J. C., Curry, S. M., Clark, A. F., & McDowell, C. M. (2018). BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork. Investigative ophthalmology & visual science, 59(5), 2154-2166.

Yu, W., & Chai, H. (2017). Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF‑β/Smad pathway in vitro and in vivo. Oncology letters, 14(4), 4793-4799.

Bai, L., Chu, G., Wang, W., Xiang, A., & Yang, G. (2017). BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-β signaling. Theriogenology, 100, 24-31.

Wang, X., Li, M., Hu, M., Wei, P., & Zhu, W. (2017). BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway. Oncology reports, 37(5), 3046-3054.

Yang, Y., Guo, C., Liao, B., Cao, J., Liang, C., & He, X. (2017). BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. International journal of molecular medicine, 39(2), 423-429.

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For research use only. Not intended for any clinical use.

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