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Mouse Anti-APOM Recombinant Antibody (4C7) (CBMAB-A3275-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
APOM (AAH20683, 23 a.a. ~ 188 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Apolipoprotein M
Introduction
APOM is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through th
Entrez Gene ID
55937
UniProt ID
O95445
Alternative Names
Apolipoprotein M; Protein G3a; Apo-M; NG20; G3a; Alternative Name: G3a, NG20; NG20-Like Protein; HSPC336; ApoM;
Function
Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
Biological Process
Cholesterol efflux Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
High-density lipoprotein particle assembly Source: BHF-UCL
High-density lipoprotein particle clearance Source: BHF-UCL
High-density lipoprotein particle remodeling Source: BHF-UCL
Lipoprotein metabolic process Source: Ensembl
Negative regulation of plasma lipoprotein oxidation Source: BHF-UCL
Response to glucose Source: Ensembl
Retinoid metabolic process Source: Reactome
Reverse cholesterol transport Source: BHF-UCL
Cellular Location
Secreted. Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).
More Infomation

Hajny, S., Christoffersen, M., Dalila, N., Nielsen, L. B., Tybjærg-Hansen, A., & Christoffersen, C. (2020). Apolipoprotein M and risk of type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism, 105(9), 3046-3057.

Kobayashi, T., Kurano, M., Nanya, M., Shimizu, T., Ohkawa, R., Tozuka, M., & Yatomi, Y. (2020). Glycation of HDL polymerizes apolipoprotein M and attenuates its capacity to bind to sphingosine 1-phosphate. Journal of Atherosclerosis and Thrombosis, 55699.

Wang, M., Luo, G. H., Liu, H., Zhang, Y. P., Wang, B., Di, D. M., ... & Xu, N. (2019). Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways. Molecular medicine reports, 19(2), 1272-1283.

Sramkova, V., Berend, S., Siklova, M., Caspar-Bauguil, S., Carayol, J., Bonnel, S., ... & Viguerie, N. (2019). Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction. The American journal of clinical nutrition, 109(6), 1499-1510.

Liu, Y., & Tie, L. (2019). Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway. BMC cardiovascular disorders, 19(1), 1-9.

Yang, L., Li, T., Zhao, S., & Zhang, S. (2019). Expression of apolipoprotein M and its association with adiponectin in an obese mouse model. Experimental and Therapeutic Medicine, 18(3), 1685-1692.

Yu, M., Pan, L., Sang, C., Mu, Q., Zheng, L., Luo, G., & Xu, N. (2019). Apolipoprotein M could inhibit growth and metastasis of SMMC7721 cells via vitamin D receptor signaling. Cancer management and research, 11, 3691.

Kurano, M., Tsuneyama, K., Morimoto, Y., Nishikawa, M., & Yatomi, Y. (2019). Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper‐IgA mice. The FASEB Journal, 33(4), 5181-5195.

Croyal, M., Billon-Crossouard, S., Goulitquer, S., Aguesse, A., León, L., Fall, F., ... & Krempf, M. (2018). Stable isotope kinetic study of ApoM (apolipoprotein M). Arteriosclerosis, thrombosis, and vascular biology, 38(1), 255-261.

Bosteen, M. H., Svarrer, E. M. M., Bisgaard, L. S., Martinussen, T., Madsen, M., Nielsen, L. B., ... & Pedersen, T. X. (2017). Effects of apolipoprotein M in uremic atherosclerosis. Atherosclerosis, 265, 93-101.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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