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Mouse Anti-ADGRB2 Recombinant Antibody (V2-611530) (CBMAB-A0702-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611530
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
BAI2 (NP_001694, 22 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor B2
Introduction
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq]
Entrez Gene ID
576
UniProt ID
O60241
Function
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcineurin-NFAT signaling cascade
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Negative regulation of angiogenesis
Peripheral nervous system development
Cellular Location
Cell membrane
Topology
Extracellular: 33-936 aa
Helical: 937-957 aa
Cytoplasmic: 958-965 aa
Helical: 966-986 aa
Extracellular: 987-994 aa
Helical: 995-1015 aa
Cytoplasmic: 1016-1036 aa
Helical: 1037-1057 aa
Extracellular: 1058-1078 aa
Helical: 1079-1099 aa
Cytoplasmic: 1100-1121 aa
Helical: 1122-1142 aa
Extracellular: 1143-1153 aa
Helical: 1154-1174 aa
Cytoplasmic: 1175-1585 aa
PTM
Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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