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Rabbit Anti-ADD1 Recombinant Antibody (V2-179872) (CBMAB-A1252-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
V2-179872
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Asp643 of human α-adducin protein.
Host Species
Rabbit
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adducin 1
Introduction
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-add
Entrez Gene ID
Human118
Monkey700805
UniProt ID
HumanP35611
MonkeyH2QP46
Alternative Names
Adducin 1; Adducin 1 (Alpha); Alpha-Adducin; ADDA; Erythrocyte Adducin Alpha Subunit; Erythrocyte Adducin Subunit Alpha;
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Biological Process
Actin cytoskeleton organization
Actin filament bundle assembly
Barbed-end actin filament capping
Cell morphogenesis
Cellular response to calcium ion
Cell volume homeostasis
Erythrocyte differentiation
Hemoglobin metabolic process
Homeostasis of number of cells within a tissue
In utero embryonic development
IRE1-mediated unfolded protein response
Multicellular organism growth
Positive regulation of adherens junction organization
Positive regulation of establishment of endothelial barrier
Positive regulation of protein binding
Transmembrane transport
Cellular Location
Cell membrane; Cytoskeleton
More Infomation

Yermolenko, S., Chumachenko, Y., Orlovskyi, V., Moiseyenko, I., & Orlovskyi, O. (2021). The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population. International Journal of Hypertension, 2021.

Su, C. Y., Yan, R. L., Hsu, W. H., Chu, C. T., Chang, H. C., Lai, C. C., ... & Chen, H. C. (2019). Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration. Scientific reports, 9(1), 1-11.

Gupta, S., Jhawat, V., Agarwal, B. K., Roy, P., & Saini, V. (2019). Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension. Current hypertension reviews, 15(2), 123-134.

Hsu, W. H., Wang, W. J., Lin, W. Y., Huang, Y. M., Lai, C. C., Liao, J. C., & Chen, H. C. (2018). Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2. EMBO reports, 19(8), e45607.

Park, M. Y., & Lee, M. S. (2018). Effects of Sodium Intake on the Association between the Salt-Sensitive Gene, Alpha-Adducin 1 (ADD1), and Inflammatory Cytokines in the Prevalence of Children Obesity. Journal of Lipid and Atherosclerosis, 7(2), 98-109.

Bayoumy, N. M., El-Shabrawi, M. M., Leheta, O. F., & Omar, H. H. (2017). α-Adducin gene promoter DNA methylation and the risk of essential hypertension. Clinical and Experimental Hypertension, 39(8), 764-768.

Luo, C., & Shen, J. (2017). Adducin in tumorigenesis and metastasis. Oncotarget, 8(29), 48453.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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