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Mouse Anti-ABHD5 Recombinant Antibody (V2-179095) (CBMAB-A0336-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179095
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
abhydrolase domain containing 5
Introduction
ABHD5 belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfami
Entrez Gene ID
51099
UniProt ID
Q8WTS1
Alternative Names
Abhydrolase Domain Containing 5; Abhydrolase Domain-Containing Protein 5; Lipid Droplet-Binding Protein CGI-58; EC 2.3.1.51; NCIE2; 1-Acylglycerol-3-Phosphate O-Acyltransferase ABHD5;
Function
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity).
Biological Process
Cell differentiation
Fatty acid metabolic process
Lipid homeostasis
Negative regulation of sequestering of triglyceride
Phosphatidic acid biosynthetic process
Positive regulation of lipoprotein lipase activity
Positive regulation of triglyceride catabolic process
Cellular Location
Cytoplasm; Cytosol; Lipid droplet. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).
Involvement in disease
An autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Clinical characteristics are congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss and developmental delay. The disorder presents at birth with generalized, fine, white scaling of the skin and a variable degree of erythema resembling non-bullous congenital ichthyosiform erythroderma.
More Infomation

Peng, H. Y., Li, H. P., & Li, M. Q. (2020). Downregulated ABHD5 aggravates insulin resistance of trophoblast cells during gestational diabetes mellitus. Reproductive Sciences, 27(1), 233-245.

Liang, M., Chen, X., Wang, L., Qin, L., Wang, H., Sun, Z., ... & Geng, B. (2020). Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression. Journal of Experimental & Clinical Cancer Research, 39(1), 1-17.

Shang, S., Ji, X., Zhang, L., Chen, J., Li, C., Shi, R., ... & Miao, H. (2019). Macrophage ABHD5 suppresses NFκB-Dependent matrix metalloproteinase expression and cancer metastasis. Cancer research, 79(21), 5513-5526.

Jebessa, Z. H., Shanmukha, K. D., Dewenter, M., Lehmann, L. H., Xu, C., Schreiter, F., ... & Backs, J. (2019). The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nature metabolism, 1(11), 1157-1167.

Zhou, Q., Wang, F., Zhou, K., Huang, K., Zhu, Q., Luo, X., ... & Shi, Z. (2019). Oncogenic role of ABHD5 in endometrial cancer. Cancer management and research, 11, 2139.

Wang, X., Khan, R., Raza, S. H. A., Li, A., Zhang, Y., Liang, C., ... & Zan, L. (2019). Molecular characterization of ABHD5 gene promoter in intramuscular preadipocytes of Qinchuan cattle: Roles of Evi1 and C/EBPα. Gene, 690, 38-47.

Eskiocak, A. H., Missaglia, S., Moro, L., Durdu, M., & Tavian, D. (2019). A novel mutation of ABHD5 gene in a Chanarin Dorfman patient with unusual dermatological findings. Lipids in health and disease, 18(1), 1-6.

Lee, H. J., & Chang, B. (2017). The Roles of ABHD5 (Abhydrolase Domain Containing 5) in Plin2-Deficiency Mediated Autophagy Augmentation. Circulation, 136(suppl_1), A16203-A16203.

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For research use only. Not intended for any clinical use.

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