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Mouse Anti-ABCF1 Recombinant Antibody (V2-179065) (CBMAB-A0301-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179065
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF

Basic Information

Immunogen
ABCF1 (NP_001081, 642-739 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily F Member 1
Introduction
ABCF1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Entrez Gene ID
23
UniProt ID
Q8NE71
Alternative Names
ATP Binding Cassette Subfamily F Member 1; ATP-Binding Cassette, Sub-Family F (GCN20), Member 1; TNF-Alpha-Stimulated ABC Protein; ABC50; ATP-Binding Cassette 50 (TNF-Alpha Stimulated); ATP-Binding Cassette Sub-Family F Member 1;
Function
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
Biological Process
Inflammatory response
Positive regulation of translation
Translation
Translational initiation
Transmembrane transport
Cellular Location
Nucleoplasm; Nucleus envelope; Cytoplasm
PTM
Isoform 2 is phosphorylated at phosphoserine and phosphothreonine. Isoform 2 phosphorylation on Ser-109 and Ser-140 by CK2 inhibits association of EIF2 with ribosomes.
More Infomation

Choi, E. B., Vodnala, M., Zerbato, M., Wang, J., Ho, J. J., Inouye, C., & Fong, Y. W. (2021). ATP-binding cassette protein ABCF1 couples transcription and genome surveillance in embryonic stem cells through low complexity domain. bioRxiv, 2020-05.

Choi, E. B., Vodnala, M., Zerbato, M., Wang, J., Ho, J. J., Inouye, C., & Fong, Y. W. (2021). ATP-binding cassette protein ABCF1 couples gene transcription with maintenance of genome integrity in embryonic stem cells. bioRxiv, 2020-05.

Meng, X., Yang, X., Wu, Z., Shen, Q., Miao, L., Zheng, Y., ... & Wang, J. (2020). Identification and transcriptional response of ATP‐binding cassette transporters to chlorantraniliprole in the rice striped stem borer, Chilo suppressalis. Pest management science, 76(11), 3626-3635.

Fung, S. W., Cheung, P. F. Y., Yip, C. W., Ng, L. W. C., Cheung, T. T., Chong, C. C. N., ... & Cheung, S. T. (2019). The ATP-binding cassette transporter ABCF1 is a hepatic oncofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma. Cancer letters, 457, 98-109.

Lim, L. W. K., Ying, T. H., Aminan, A. W., Jumaan, A. Q., Moktar, M. Z., Yen, T. S., ... & Sulaiman, B. (2018). Phylogenetic and Expression of Atp-Binding Cassette Transporter Genes in Rasbora sarawakensis. Pertanika Journal of Tropical Agricultural Science, 41(3).

Qu, L., Jiang, Y., Cheng, C., Wu, D., Meng, B., Chen, Z., ... & Liu, Z. J. (2018). Crystal structure of ATP-bound human ABCF1 demonstrates a unique conformation of ABC proteins. Structure, 26(9), 1259-1265.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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