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Mouse Anti-ABCD3 Recombinant Antibody (V2-179063) (CBMAB-A0299-YC)


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Published Data
Mouse Anti-ABCD3 Recombinant Antibody (F-1) (CBMAB-A0299-YC) in WB
B16F1 cells were pre-treated with α-MSH (0.5 μM) for 48 h and then further incubated with nalfurafine hydrochloride (Nalf, 100 μM). Cells were harvested and analyzed by Western blotting with the indicated ABCD3 (peroxisome). ...View More
Lee, H. J., Kim, S. H., Kim, Y. H., Kim, S. H., Oh, G. S., Bae, J. E., ... & Cho, D. H. (2022). Nalfurafine Hydrochloride, a κ-Opioid Receptor Agonist, Induces Melanophagy via PKA Inhibition in B16F1 Cells. Cells, 12(1), 146.
Mouse Anti-ABCD3 Recombinant Antibody (F-1) (CBMAB-A0299-YC) in IF
Peroxisomes were labeled with ABCD3 and were observed with fluorescence microscopy. Scale bar = 10 μm. Mean gray value were analyzed by Image J. ...View More
Lin, X., Zhao, Q., Fu, B., Xiong, Y., Zhang, S., Xu, S., & Wu, H. (2022). ISOC1 Modulates Inflammatory Responses in Macrophages through the AKT1/PEX11B/Peroxisome Pathway. Molecules, 27(18), 5896.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179063
Antibody Isotype
IgG1
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Raised against amino acids 280-475 of ABCD3 of human origin
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP-binding cassette, sub-family D (ALD), member 3
Introduction
ABCD3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Entrez Gene ID
5825
UniProt ID
P28288
Alternative Names
ATP Binding Cassette Subfamily D Member 3; ATP-Binding Cassette, Sub-Family D (ALD), Member 3; 70 KDa Peroxisomal Membrane Protein; PXMP1; PMP70; DJ824O18.1 (ATP-Binding Cassette, Sub-Family D (ALD), Member 3 (PMP70, PXMP1)); Peroxisomal Membrane Protein
Function
Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Biological Process
Fatty acid beta-oxidation
Fatty acid biosynthetic process
Lipid transport
Long-chain fatty acid import into peroxisome
Peroxisome organization
Protein import into peroxisome membrane
Response to drug
Response to organic cyclic compound
Very long-chain fatty acid catabolic process
Cellular Location
Peroxisome membrane
Involvement in disease
An autosomal recessive disorder characterized by hepatosplenomegaly, hepatic fibrosis, progressive liver failure, and accumulation of peroxisomal C27-bile acid intermediates in plasma.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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