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Mouse Anti-ABCC11 Recombinant Antibody (V2-179000) (CBMAB-A0235-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179000
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 433-533 from human ABCC11 (NP_115972) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
ELISA1:30-1:3,000
IF(ICC)1:50-1:500
IP1-2 µl per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Introduction
ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GC
Entrez Gene ID
85320
UniProt ID
Q96J66
Alternative Names
ATP Binding Cassette Subfamily C Member 11; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 11; Multidrug Resistance-Associated Protein 8; MRP8; ATP-Binding Cassette Transporter Sub-Family C Member 11; ATP-Binding Cassette Sub-Family C Member 11;
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E217betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation.
Biological Process
Bile acid and bile salt transport
Leukotriene transport
Organic anion transport
Purine nucleotide transport
Transmembrane transport
Xenobiotic transport
Cellular Location
Cell membrane; Apical cell membrane; Vacuole membrane; Cytoplasmic vesicle membrane
More Infomation

Chen, B. C., Wang, H., & Wu, B. (2020). Effect of “HuChou San” on ABCC11 mRNA levels and MRP8 protein expression in skin tissue from bilateral axilla of axillary osmidrosis patients. Tropical Journal of Pharmaceutical Research, 19(10), 2041-2045.

Funazo, T., Tsuji, T., Ozasa, H., Furugaki, K., Yoshimura, Y., Oguri, T., ... & Hirai, T. (2020). Acquired Resistance to Alectinib in ALK-Rearranged Lung Cancer Due to ABCC11/MRP8 Overexpression in a Clinically Paired Resistance Model. Molecular cancer therapeutics, 19(6), 1320-1327.

Shi, M., Wang, S., Zhang, Y., Wang, S., Zhao, J., Feng, H., ... & Xie, X. (2020). Genome-wide characterization and expression analysis of ATP-binding cassette (ABC) transporters in strawberry reveal the role of FvABCC11 in cadmium tolerance. Scientia Horticulturae, 271, 109464.

Mao, X., He, Z., Zhou, F., Huang, Y., & Zhu, G. (2019). Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer. Medicine, 98(50).

Mesci, S., Marakli, S., Yazgan, B., & YILDIRIM, T. (2019). The effect of ATP-binding cassette (ABC) transporters in human cancers. International Journal of Science Letters, 1(1), 14-19.

Soraas, L., & Stebbing, J. (2018). Geographic variation in EGFR mutation frequency in lung adenocarcinoma may be explained by interethnic genetic variation. Journal of Thoracic Oncology, 13(3), 454-458.

Tun-Yhong, W., Chinpaisal, C., Pamonsinlapatham, P., & Kaewkitichai, S. (2017). Tenofovir disoproxil fumarate is a new substrate of ATP-binding cassette subfamily C member 11. Antimicrobial agents and chemotherapy, 61(4), e01725-16.

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For research use only. Not intended for any clinical use.

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