Mouse Anti-ABCB9 Recombinant Antibody (V2-178985) (CBMAB-A0220-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

V2-178985

Antibody Isotype

IgG2b, κ

Application

ELISA, ICC, IF, WB

Basic Information

Immunogen

ABCB9 (NP_062571, 482-580 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ATP-binding cassette, sub-family B (MDR/TAP), member 9

Introduction

ABCB9 belongs to the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,

Entrez Gene ID

23457

UniProt ID

Q9NP78

Alternative Names

ATP Binding Cassette Subfamily B Member 9; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 9; ABC Transporter 9 Protein; TAP-Like Protein; TAPL; ATP-Binding Cassette Sub-Family B Member 9; ATP-Binding Cassette Transporter 9;

Function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.

Biological Process

Antigen processing and presentation of endogenous peptide antigen via MHC class I
Peptide transport
Protein transport
Transmembrane transport

Cellular Location

Lysosome membrane. May be located in membrane rafts.

More Infomation

References

Szakacs, G., & Abele, R. (2020). An inventory of lysosomal ABC transporters. FEBS letters, 594(23), 3965-3985.

Blajan, I., Miersch, H., Schmidt, D., Kristiansen, G., Perner, S., Ritter, M., ... & Klümper, N. (2020). Comprehensive Analysis of the ATP-binding Cassette Subfamily B Across Renal Cancers Identifies ABCB8 Overexpression in Phenotypically Aggressive Clear Cell Renal Cell Carcinoma. European Urology Focus.

Zhang, Y., Zhang, Y., Wang, J., Yang, J., & Yang, G. (2020). Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer. Oncology letters, 19(5), 3567-3577.

Hou, L., Zhang, X., Jiao, Y., Li, Y., Zhao, Y., Guan, Y., & Liu, Z. (2019). ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer. Medicine, 98(19).

Zhang, S., Guo, J., Liang, M., Qi, J., Wang, Z., Jian, X., ... & Li, Z. (2019). miR-196a promotes proliferation and inhibits apoptosis of immature porcine sertoli cells. DNA and cell biology, 38(1), 41-48.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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