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Mouse Anti-ABCA6 Recombinant Antibody (V2-178914) (CBMAB-A0149-YC)


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Published Data
Mouse Anti-ABCA6 Recombinant Antibody (2F1) (CBMAB-A0149-YC) in WB
Human ABCA6 p.Cys1359Arg and corresponding mouse abca6 p.Cys1366Arg disrupt the protein stability. Equal amounts of plasmids expressing Flag tagged wild type (WT) or mutant ABCA6 were transfected into 293T cells. Forty-eight hours later, cells were collected and subjected to immunoblot or RT-PCR analysis as described in Methods. ...View More
He, B., Kang, S., Chen, Z., Liu, X., Wang, J., Li, X., ... & Wang, Y. (2021). Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabolism in mice or hamster. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1866(11), 159006.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-178914
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 53-150 from ABCA6 (NP_525023) with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily A Member 6
Introduction
ABCA6 belongs to the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, a
Entrez Gene ID
23460
UniProt ID
Q8N139
Alternative Names
ATP Binding Cassette Subfamily A Member 6; ATP-Binding Cassette, Sub-Family A (ABC1), Member 6; ATP-Binding Cassette Sub-Family A Member 6; ATP-Binding Cassette A6; ABC Transporter ABCA6; EC 2.5.1.19; EC 3.6.3.25; EST155051; EC 3.6.3;
Function
Probable transporter which may play a role in macrophage lipid transport and homeostasis.
Biological Process
Lipid transport
Cellular Location
Golgi apparatus membrane
More Infomation

Xu, J., Zhou, Y., Yang, Y., Lv, C., Liu, X., & Wang, Y. (2020). Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection. BMC immunology, 21, 1-11.

Huang, R., Yan, G., Sun, H., Zhang, J., Song, D., Kong, R., ... & Huang, Z. (2020). Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma. Bioscience reports, 40(7), BSR20201001.

Breuss, M. W., Mamerto, A., Renner, T., & Waters, E. R. (2020). The Evolution of the Mammalian ABCA6-like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories. Genome biology and evolution, 12(11), 2093-2106.

Imperio, G. E., Javam, M., Lye, P., Constantinof, A., Dunk, C. E., Reis, F. M., ... & Bloise, E. (2019). Gestational age‐dependent gene expression profiling of ATP‐binding cassette transporters in the healthy human placenta. Journal of cellular and molecular medicine, 23(1), 610-618.

Briz, O., Perez-Silva, L., Al-Abdulla, R., Abete, L., Reviejo, M., Romero, M. R., & Marin, J. J. (2019). What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugs. Expert opinion on drug metabolism & toxicology, 15(7), 577-593.

Tachikawa, M., Toki, H., Watanabe, M., Tomi, M., Hosoya, K. I., & Terasaki, T. (2018). Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels. Anatomical science international, 93(4), 456-463.

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For research use only. Not intended for any clinical use.

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