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Mouse Anti-ABCA1 Recombinant Antibody (V2-178895) (CBMAB-A0123-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-178895
Antibody Isotype
IgM, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa86-185 from human ABCA1 with GST tag (NP_005493).
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Ascites
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily A Member 1
Introduction
ABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2
Entrez Gene ID
19
UniProt ID
O95477
Alternative Names
ATP Binding Cassette Subfamily A Member 1; ATP-Binding Cassette, Sub-Family A (ABC1), Member 1; Cholesterol Efflux Regulatory Protein; ABC-1; ABC1; CERP; ATP-Binding Cassette Sub-Family A Member 1; ATP-Binding Cassette Transporter A1; ATP-Binding Cassette
Function
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cellular response to low-density lipoprotein particle stimulus
Cholesterol efflux
Cholesterol homeostasis
Cholesterol metabolic process
Endosomal transport
Export across plasma membrane
G protein-coupled receptor signaling pathway
High-density lipoprotein particle assembly
Intracellular cholesterol transport
Intracellular receptor signaling pathway
Lipid transport
Lysosome organization
Negative regulation of cholesterol storage
Negative regulation of macrophage derived foam cell differentiation
Phospholipid efflux
Phospholipid homeostasis
Phospholipid translocation
Platelet dense granule organization
Positive regulation of cholesterol efflux
Positive regulation of high-density lipoprotein particle assembly
Protein secretion
Protein transmembrane transport
Regulation of Cdc42 protein signal transduction
Regulation of high-density lipoprotein particle assembly
Regulation of metabolic process
Response to laminar fluid shear stress
Reverse cholesterol transport
Signal release
Cellular Location
Endosome; Cell membrane
Involvement in disease
An autosomal recessive disorder characterized by near absence of plasma high density lipoproteins, low serum HDL cholesterol, and massive tissue deposition of cholesterol esters. Clinical features include large yellow-orange tonsils, hepatomegaly, splenomegaly, enlarged lymph nodes, and often sensory polyneuropathy.
An autosomal dominant disorder characterized by decreased plasma high density lipoproteins, moderately low HDL cholesterol, a reduction in cellular cholesterol efflux, and susceptibility to premature coronary artery disease.
Topology
Helical: 22-42 aa
Extracellular: 43-639 aa
Helical: 640-1371 aa
Extracellular: 1372-1656 aa
Helical: 1657-1872 aa
PTM
Phosphorylation on Ser-2054 regulates phospholipid efflux.
Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane
More Infomation

Wang, S. M., Lin, W. C., Lin, H. Y., Chen, Y. L., Ko, C. Y., & Wang, J. M. (2021). CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma. Cell Death Discovery, 7(1), 1-11.

Li, J., Wen, M., Zhang, Z., Qiu, Z., & Sun, Y. (2020). The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population. Open Medicine, 15(1), 274-282.

Jiang, P., Zhao, Z., Li, X., Wang, M., Xia, L., Cao, Y., ... & Fang, X. (2020). RNA interference mediated knockdown of ATP binding cassette subfamily A member 1 decreases the triglyceride content of bovine mammary epithelial cells. Pakistan Journal of Zoology, 52(1), 239.

Chen, Z., Chu, S., Wang, X., Fan, Y., Zhan, T., Arbab, A. A. I., ... & Yang, Z. (2019). MicroRNA-106b regulates milk fat metabolism via ATP binding cassette subfamily A member 1 (ABCA1) in bovine mammary epithelial cells. Journal of agricultural and food chemistry, 67(14), 3981-3990.

Yan, H., Cheng, L., Jia, R., Yao, H., Wu, H., Shen, Y., ... & Zhang, Z. (2019). ATP-binding cassette sub-family a member1 gene mutation improves lipid metabolic abnormalities in diabetes mellitus. Lipids in health and disease, 18(1), 1-6.

Hou, L., Tang, S., Wu, B. J., Ong, K. L., Westerterp, M., Barter, P. J., ... & Rye, K. A. (2019). Apolipoprotein A‐l improves pancreatic β‐cell function independent of the ATP‐binding cassette transporters ABCA1 and ABCG1. The FASEB Journal, 33(7), 8479-8489.

Jung, D., Cao, S., Liu, M., & Park, S. (2018). A meta-analysis of the associations between the ATP-binding cassette transporter ABCA1 R219K (rs2230806) polymorphism and the risk of type 2 diabetes in Asians. Hormone and Metabolic Research, 50(04), 308-316.

Wang, L., Fumoto, T., Masumoto, S., Shoji, T., Miura, T., Naraoka, M., ... & Ohkuma, H. (2017). Regression of atherosclerosis with apple procyanidins by activating the ATP-binding cassette subfamily A member 1 in a rabbit model. Atherosclerosis, 258, 56-64.

Hafiane, A., & Genest, J. (2017). ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis. Atherosclerosis, 257, 90-99.

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For research use only. Not intended for any clinical use.

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