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Mouse Anti-SELENOP Recombinant Antibody (CBXS-4716) (CBMAB-S1947-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4716
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Selenoprotein-P purified from human plasma
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, 0.01% BSA, 0.15 M NaCl, 50% glycerol
Preservative
0.03% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Selenop
Introduction
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
6414
UniProt ID
P49908
Alternative Names
Selenoprotein P; Selenoprotein P, Plasma, 1; SEPP1; SELP; SEP; SEPP;
Function
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
Biological Process
Biological Process brain developmentIEA:Ensembl
Biological Process locomotory behaviorIEA:Ensembl
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process regulation of growthIEA:Ensembl
Biological Process response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to selenium ionIEA:Ensembl
Biological Process selenium compound metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sexual reproductionIEA:Ensembl
Cellular Location
Secreted
Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.
PTM
Phosphorylation sites are present in the extracellular medium.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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