Mouse Anti-DENR Recombinant Antibody (1542CT106.51.79) (CBMAB-D0703-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1542CT106.51.79

Antibody Isotype

IgG

Application

WB, IHC-P, ICC, IF, FC

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Density Regulated Re-Initiation And Release Factor

Introduction

DENR is a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants.

Entrez Gene ID

8562

UniProt ID

O43583

Alternative Names

Density Regulated Re-Initiation And Release Factor; Density-Regulated Protein; SMAP-3; DRP1; DRP; Smooth Muscle Cell Associated Protein-3; Smooth Muscle Cell-Associated Protein 3; Protein DRP1;

Function

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Biological Process

Formation of translation preinitiation complex Source: UniProtKB
IRES-dependent viral translational initiation Source: UniProtKB
Ribosome disassembly Source: UniProtKB
Translation reinitiation Source: GO_Central

More Infomation

References

Chen, B., Hu, J., Hu, X., Chen, H., Bao, R., Zhou, Y., ... & Li, H. B. (2022). DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature communications, 13(1), 1-14.

Yu, S. E. (2021). The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation. Acta Naturae (англоязычная версия), 13(2), 98-105.

Wang, D., Wang, L., Ren, C., Zhang, P., Wang, M., & Zhang, S. (2019). High expression of density‑regulated re‑initiation and release factor drives tumourigenesis and affects clinical outcome. Oncology Letters, 17(1), 141-148.

Ahmed, Y. L., Schleich, S., Bohlen, J., Mandel, N., Simon, B., Sinning, I., & Teleman, A. A. (2018). DENR–MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. PLoS biology, 16(6), e2005160.

Lomakin, I. B., Stolboushkina, E. A., Vaidya, A. T., Zhao, C., Garber, M. B., Dmitriev, S. E., & Steitz, T. A. (2017). Crystal structure of the human ribosome in complex with DENR-MCT-1. Cell reports, 20(3), 521-528.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-DENR Recombinant Antibody (1H3)

Recombinant Mouse Anti-DENR Antibody (CBAb081)

Mouse Anti-DENR Recombinant Antibody (CAP621)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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